2016 Pitt Panthers, 8-5 (5-3 ACC)
| 2016 | 9/3 | Villanova | Heinz Field | W, 28-7 |
| 2016 | 9/10 | Penn State | Heinz Field | W, 42-39 |
| 2016 | 9/17 | Oklahoma State | Stillwater, OK | L, 38-45 |
| 2016 | 9/24 | North Carolina | Chapel Hill, NC | L, 36-37 |
| 2016 | 10/1 | Marshall | Heinz Field | W, 43-27 |
| 2016 | 10/8 | Georgia Tech | Heinz Field | W, 37-34 |
| 2016 | 10/15 | Virginia | Charlottesville, VA | W, 45-31 |
| 2016 | 10/27 | Virginia Tech | Heinz Field | L, 36-39 |
| 2016 | 11/5 | Miami (Fla.) | Miami, FL | L, 28-51 |
| 2016 | 11/12 | Clemson | Clemson, SC | W, 43-42 |
| 2016 | 11/19 | Duke | Heinz Field | W, 56-14 |
| 2016 | 11/26 | Syracuse | Heinz Field | W, 76-61 |
| 2016 | 12/28 | Northwestern (Pinstripe Bowl) | New York, NY | L, 24-31 |
2017 Pitt Panthers, 5-7 (3-5 ACC)
| 2017 | 9/2 | Youngstown State | Heinz Field | W, 28-21 |
| 2017 | 9/9 | Penn State | State College, PA | L, 14-33 |
| 2017 | 9/16 | Oklahoma State | Heinz Field | L, 21-59 |
| 2017 | 9/23 | Georgia Tech | Atlanta, GA | L, 17-35 |
| 2017 | 9/30 | Rice | Heinz Field | W, 42-10 |
| 2017 | 10/7 | Syracuse | Syracuse, NY | L, 24-27 |
| 2017 | 10/14 | NC State | Heinz Field | L, 17-35 |
| 2017 | 10/21 | Duke | Durham, NC | W, 24-17 |
| 2017 | 10/28 | Virginia | Heinz Field | W, 31-14 |
| 2017 | 11/9 | North Carolina | Heinz Field | L, 34-31 |
| 2017 | 11/19 | Virginia Tech | Blacksburg, VA | L, 14-20 |
| 2017 | 11/24 | Miami (Fla.) | Heinz Field | W, 24-14 |
2018 Pitt Panthers
| 2018 | 9/1 | Albany | Heinz Field | |
| 2018 | 9/8 | Penn State | Heinz Field | |
| 2018 | TBA | Duke | Heinz Field | |
| 2018 | TBA | Georgia Tech | Heinz Field | |
| 2018 | 9/29 | UCF | Orlando, FL | |
| 2018 | TBA | Syracuse | Syracuse, NY | |
| 2018 | 10/13 | Notre Dame | South Bend, IN | |
| 2018 | TBA | Virginia Tech | Heinz Field | |
| 2018 | TBA | Miami (Fla.) | Miami, FL | |
| 2018 | TBA | North Carolina | Chapel Hill, NC | |
| 2018 | TBA | Virginia | Charlottesville, VA | |
| 2018 | TBA | Wake Forest | Winston Salem, NC |
2019 Pitt Panthers
| 2019 | 8/31 | Delaware | Heinz Field | |
| 2019 | 9/7 | Ohio | Heinz Field | |
| 2019 | 9/14 | Penn State | State College, PA | |
| 2019 | 9/21 | UCF | Heinz Field | |
| 2019 | TBA | Miami (Fla.) | Heinz Field | |
| 2019 | TBA | North Carolina | Heinz Field | |
| 2019 | TBA | Virginia | Heinz Field | |
| 2019 | TBA | Boston College | Heinz Field | |
| 2019 | TBA | Duke | Durham, NC | |
| 2019 | TBA | Georgia Tech | Atlanta, GA | |
| 2019 | TBA | Syracuse | Syracuse, NY | |
| 2019 | TBA | Virginia Tech | Blacksburg, VA |
2020 Pitt Panthers
| 2020 | 9/5 | Richmond | Heinz Field | |
| 2020 | 9/26 | Marshall | Huntington, WV | |
| 2020 | TBA | Notre Dame | Heinz Field | |
| 2020 | TBA | TBA | TBA | |
| 2020 | TBA | Duke | Heinz Field | |
| 2020 | TBA | Georgia Tech | Heinz Field | |
| 2020 | TBA | Syracuse | Heinz Field | |
| 2020 | TBA | Virginia Tech | Heinz Field | |
| 2020 | TBA | Miami (Fla.) | Miami, FL | |
| 2020 | TBA | North Carolina | Chapel Hill, NC | |
| 2020 | TBA | Virginia | Charlottesville, VA | |
| 2020 | TBA | Florida State | Tallahassee, FL |
